Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a rare, benign vascular disorder characterized by the proliferation of blood vessels accompanied by an abnormal increase in eosinophils, a type of white blood cell. It typically affects the skin and subcutaneous tissues, although it can also involve deeper structures such as muscles and bones.
ALHE often presents as firm, pink or flesh-colored nodules or papules that may be single or multiple. These lesions are commonly found on the head and neck regions, particularly around the ears, scalp, forehead, and eyelids. Although most cases of ALHE are asymptomatic, some individuals may experience tenderness, itching, or pain in the affected areas.
The underlying cause of ALHE remains unknown, and it predominantly affects young to middle-aged adults. There is no specific diagnostic test for ALHE, and the diagnosis is typically made based on clinical and histopathological findings.
Histologically, ALHE is characterized by a proliferation of small blood vessels lined by endothelial cells within a background of numerous eosinophils and lymphoid cells. These findings help to differentiate ALHE from other conditions with similar clinical features.
Treatment options for ALHE depend on the severity and extent of the lesions. Surgical excision is often considered the primary treatment, although recurrence is common. Other therapeutic approaches include radiation therapy, cryotherapy, laser therapy, and systemic immunomodulatory agents. Regular follow-up is necessary due to the potential for lesions to recur or persist over time.
In summary, Angiolymphoid Hyperplasia with Eosinophilia is a rare vascular disorder involving the abnormal growth of blood vessels and an increase in eosinophils. It presents as pink or flesh-colored nodules primarily on the head and neck regions and
